xanthine oxidase การใช้

• It is caused by a deficiency of the enzyme xanthine oxidase.
• This pathway also is independent of the enzyme activity of xanthine oxidase.
• By inhibiting xanthine oxidase, it reduces uric acid production.
• Inhibition of xanthine oxidase has been proposed as a mechanism for improving cardiovascular health.
• *Alloxanthine is an inhibitor of xanthine oxidase.
• AO is very similar in amino acid sequence to xanthine oxidase ( XO ).
• Xanthine oxidase inhibitors block uric acid production.
• Other enzymes capable of producing superoxide are xanthine oxidase, NADPH oxidases and cytochromes P450.
• The active metabolite of allopurinol is oxypurinol, which is also an inhibitor of xanthine oxidase.
• This activity is often found in a bifunctional enzyme with xanthine oxidase ( ) activity too.
• Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.
• Enzymes that contain the molybdopterin cofactor include xanthine oxidase, DMSO reductase, sulfite oxidase, and nitrate reductase.
• Xanthine oxidase loses its function and gains ascorbase function when some of the iron atoms in XO are replaced with copper atoms.
• Type I xanthinuria has been traced directly to mutations of the " XDH " gene which mediates xanthine oxidase activity.
• Both xanthine oxidase and xanthine oxidoreductase are also present in corneal epithelium and endothelium and may be involved in oxidative eye injury.
• Models for hemerythrin, an enzyme with a diiron active site, and xanthine oxidase, a molybdoenzyme, have been examined.
• In a 24-hour urine excretion of more than 800 mg, which indicates overproduction, a xanthine oxidase inhibitor is preferred.
• Hypoxanthine is then oxidatively catabolized first to xanthine and then to uric acid, and the reaction is catalyzed by the enzyme xanthine oxidase:
• A 24-hour urine excretion of more than 800 mg, which indicates overproduction, is an indication for a xanthine oxidase inhibitor.
• Because xanthine oxidase is a metabolic pathway for uric acid formation, the xanthine oxidase inhibitor allopurinol is used in the treatment of gout.